Renowned Cardiologist's Findings Contradict Omega 3 Fish Oil Prostate Cancer Allegations
In a recent study there were alleged findings that omega 3 fish oil could cause prostate cancer. Not so, says Dr. Seth J, Baum MD.
To better understand this, let's examine Brasky's findings in the context of prior data as well as our understanding of the biology of DHA and EPA.
The Physician's Health Study in 2008 revealed a correlation between high fish consumption and improved survival in men with prostate cancer. A 2003 Harvard study of 48,000 men showed a higher intake of fish to be associated with a lower risk of prostate cancer.
Let's look at plasma levels of EPA and DHA in Brasky's trial. The reported EPA+DHA level in the plasma phospholipids was 3.62 % in the non-cancer control group and 3.74 % in the high-grade cancer group.
Second, even if there were a clear association between prostate cancer and high EPA and DHA levels, that would not prove causality.
Third, we know that genetic polymorphisms in the fatty acid desaturases are associated with an increased risk of cancer. DHA and EPA are not causing the cancers.
Fourth, we are not told the source of omega-3s in this study group. Is it mostly from fish? Some fish have very high levels of PCBs, substances known to be carcinogenic. To conclude that people should stop their FISH OIL SUPPLEMENTS when some supplements are actually far "cleaner" than fish, might therefore be very misguided.
Fifth, let's examine another population with vastly different omega-3 levels to see whether Brasky's assertions are relatable to real life. The Japanese consume eight times as much EPA and DHA as do Americans, yet their risk of prostate cancer is about one eighth of ours. One should conclude that omega-3's are protective here.
Sixth, we can't ignore the biology of the fatty acids. A plethora of data has demonstrated the anti-inflammatory impact of the omega-3 fatty acids EPA and DHA. Data have also uniformly shown the pro-inflammatory effects of trans-fatty acids. When trial conclusions fly in the face of our understanding of human biology (in this case, trans fats not being harmful while omega-3's do cause harm) we must consider them to be highly suspect.
Finally, let's not forget that EPA and DHA are considered by experts to be "essential" fats. In other words, we must consume them in order to live. Before we discard these indispensable fatty acids, let's await better clinical trials, and ones that are plausible in the context of prior literature and well-documented pathophysiology.
Many earlier trials have demonstrated a correlation between high fish consumption and low rates of prostate cancer. Some examples are: Lancet, 2001 Terry et al showed a significant correlation between high fish consumption and a low incidence of prostate cancer. The Physician's Health Study in 2008 revealed a correlation between high fish consumption and improved survival in men with prostate cancer. A 2003 Harvard study of 48,000 men showed a higher intake of fish to be associated with a lower risk of prostate cancer.
Earth-Edge Natural Health & Nutrition are offering their FISH OIL SUPPLEMENT product on sale for a very limited time period.
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